Keyword Analysis & Research: checkpoint inhibitor

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How do immune checkpoint inhibitors work?

Checkpoint inhibitors work by blocking immune checkpoints—the “brakes” of the immune system—that tumors frequently manipulate in order to shut down immune responses and protect themselves.

Is pembrolizumab a checkpoint inhibitor?

Pembrolizumab (KEYTRUDA) Checkpoint Inhibitor. This is the first FDA approval of a checkpoint inhibitor for first-line treatment of lung cancer. This approval also expands the indication in second-line treatment of lung cancer to include all patients with PD-L1-expressing NSCLC.

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