Keyword Analysis & Research: telegraph model of transcription

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492181/

One of the most popular models of gene expression is the telegraph model, a two-state model where genes are assumed to be either on or off, being able to produce mature messenger RNA (mRNA) in the on state and having no mature mRNA production in the off state [1–3]. Author: Svitlana Braichenko, James Holehouse, Ramon Grima Publish Year: 2021

Author: Svitlana Braichenko, James Holehouse, Ramon Grima

Publish Year: 2021

DA: 99 PA: 26 MOZ Rank: 45

wikipedia.org

https://en.wikipedia.org/wiki/Telegraph_process

In probability theory, the telegraph process is a memoryless continuous-time stochastic process that shows two distinct values. It models burst noise (also called popcorn noise or random telegraph signal). If the two possible values that a random variable can take are and , then the process can be described by the following master equations : and.

DA: 69 PA: 19 MOZ Rank: 25

elifesciences.org

https://elifesciences.org/articles/13051

Feb 20, 2016 · In the one state model, transcription occurs with a constant probability, which for moderately and strongly transcribed genes, will generate a low variance in their total transcribed RNA per cell. ... To explain this increased variance, the more complex random telegraph (or two state) model is often invoked (Paulsson, 2005). In this model, the ... Author: Adam M Corrigan, Edward Tunnacliffe, Danielle Cannon, Jonathan R Chubb Publish Year: 2016

Author: Adam M Corrigan, Edward Tunnacliffe, Danielle Cannon, Jonathan R Chubb

Publish Year: 2016

DA: 56 PA: 67 MOZ Rank: 51

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783999/

The primary implication of the telegraph model is that variation in gene expression is greatly increased through the process of transcriptional or translational bursting. Mathematically, transcriptional bursting means simply that many transcripts are produced from a single transcription on state 26 , 27 , 43 , 46 , 47 ; translational bursting means that many proteins … Author: Daniel R. Larson, Robert H. Singer, Daniel Zenklusen Publish Year: 2009

Author: Daniel R. Larson, Robert H. Singer, Daniel Zenklusen

Publish Year: 2009

DA: 72 PA: 44 MOZ Rank: 87

researchgate.net

https://www.researchgate.net/publication/268814506_Modelling_of_telegraph_equations_in_transmission_lines

differences in conductors. Figure 1: Telegraph wire with leakage. Let. x = distance from sending end of the cable; e (x,t) = potential at any point on the cable at any time; i (x,t) = current at ...

DA: 11 PA: 3 MOZ Rank: 63

sciencedirect.com

https://www.sciencedirect.com/science/article/pii/S0006349520305841

Sep 01, 2020 · The telegraph model of gene expression, whereby transcription switches between on and off states, is the dominant model for bursting. Recently, it was shown that the telegraph model cannot explain a number of experimental observations from perturbation data. Author: Zhixing Cao, Tatiana Filatova, Diego A. Oyarzún, Ramon Grima Publish Year: 2020

Author: Zhixing Cao, Tatiana Filatova, Diego A. Oyarzún, Ramon Grima

Publish Year: 2020

DA: 2 PA: 55 MOZ Rank: 66

researchgate.net

https://www.researchgate.net/publication/352289640_Distinguishing_between_models_of_mammalian_gene_expression_telegraph-like_models_versus_mechanistic_models/fulltext/60c21d054585157774c4f2aa/Distinguishing-between-models-of-mammalian-gene-expression-telegraph-like-models-versus-mechanistic-models.pdf

mathematical models of the telegraph model often employ probabilistic modelling techniques such as the ... and hence reveals more information on the details of transcription [15–17].

DA: 83 PA: 78 MOZ Rank: 42

royalsocietypublishing.org

https://royalsocietypublishing.org/doi/epdf/10.1098/rsif.2021.0510

Two-state models (telegraph-like models) have a successful history of predicting distributions of cellular and nascent mRNA numbers that can well fit experimental data. These models exclude key rate limiting steps, and hence it is unclear why theyare able to …

DA: 85 PA: 8 MOZ Rank: 78

github.io

https://jamesholehouse.github.io/assets/papers/telegraph.pdf

Two-state models (telegraph-like models) have a successful history of predicting distributions of cellular and nascent mRNA numbers that can well fit experimental data. These models exclude key rate limiting steps, and hence it is unclear why theyare able to …

DA: 10 PA: 65 MOZ Rank: 34

nature.com

https://www.nature.com/articles/s41467-021-24461-6

Jul 23, 2021 · c Schema of the two-state telegraph model, ... INR motif translates into a longer paused state that creates an additional rate-limiting step during transcription in vivo. In our kinetic model, the ...

DA: 10 PA: 64 MOZ Rank: 50