RAS nucleotide cycling underlies the SHP2 phosphatase ... - PubMed
7 Department of Biology, Revolution Medicines, Inc., Redwood City, CA, USA. [email protected] 8 Department of Medicine, University of California, San Francisco, ... NF1 loss or nucleotide-cycling oncogenic RAS (for example, KRAS G12C). SHP2 inhibitor treatment decreases oncogenic RAS/RAF/MEK/ERK signalling and cancer growth by ...
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