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Does targeting Alzheimer’s disease Aβ reduction affect biologic disease progression?

Models involving patients with autosomal dominant Alzheimer’s disease have suggested a lag of 10 to 20 years from the first detection of PET amyloid changes to the first detection of PET tau changes. 36 The lack of effect on the global tau load prompts questions about whether targeting Aβ reduction affects biologic disease progression.

Is variant TREM2 a risk factor for Alzheimer's disease?

Given the reported antiinflammatory role of TREM2 in the brain, the R47H substitution may lead to an increased predisposition to Alzheimer's disease through impaired containment of inflammatory processes. (Fund … Our findings strongly implicate variant TREM2 in the pathogenesis of Alzheimer's disease.

What does NEJM stand for?

The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of ...

What is the mechanism of Alzheimer's disease?

This review of Alzheimer's disease assembles a variety of findings relevant to the mechanism of the disease and ties them together using the current understanding of the basis of the loss of cognition: the accumulation of misfolded proteins, which cause oxidative and inflammatory damage to the brain and, ultimately, synaptic dysfunction.


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