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How is a mismatch repaired?

Mismatch repair. A mismatch is detected in newly synthesized DNA. The new DNA strand is cut, and a patch of DNA containing the mispaired nucleotide and its neighbors is removed. The missing patch is replaced with correct nucleotides by a DNA polymerase. A DNA ligase seals the remaining gap in the DNA backbone.

What is the correct sequence of DNA mismatch repair proteins?

In humans, seven DNA mismatch repair (MMR) proteins (MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2) work coordinately in sequential steps to initiate repair of DNA mismatches.

What is mismatch repair in E coli?

The third column shows mismatch repair, to be specific in E. coli. DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.

What are the nicks in DNA mismatch repair?

DNA mismatch repair. It is suspected that, in eukaryotes, newly synthesized lagging-strand DNA transiently contains nicks (before being sealed by DNA ligase) and provides a signal that directs mismatch proofreading systems to the appropriate strand. This implies that these nicks must be present in the leading strand,...


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