Keyword Analysis & Research: integrase inhibitor profile

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569752/

WEBHere, we review the integrase (IN) inhibitors from the discovery of the first compounds 20 years ago to the approval of two highly effective IN strand transfer inhibitors (INSTIs), raltegravir (Isentress) and elvitegravir (Stribild), and the promising clinical activity of … Author: Brian A. Johns, Andrew Spaltenstein DOI: 10.1016/B978-0-12-405880-4.00003-2 Publish Year: 2006 Published: 2013

Author: Brian A. Johns, Andrew Spaltenstein

DOI: 10.1016/B978-0-12-405880-4.00003-2

Publish Year: 2006

Published: 2013

DA: 30 PA: 27 MOZ Rank: 57

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572875/

WEBThe integrase strand transfer inhibitor (INSTI) class of antiretrovirals contributes to the enhanced safety and efficacy of modern ART regimens. Based on data demonstrating … Author: Kimberly K. Scarsi, Joshua P. Havens, Anthony T. Podany, Sean N. Avedissian, Courtney V. Fletcher Publish Year: 2020

Author: Kimberly K. Scarsi, Joshua P. Havens, Anthony T. Podany, Sean N. Avedissian, Courtney V. Fletcher

Publish Year: 2020

DA: 50 PA: 24 MOZ Rank: 2

wikipedia.org

https://en.wikipedia.org/wiki/Integrase_inhibitor

OverviewDrugs in use and under developmentSee alsoFurther readingExternal linksIntegrase inhibitors (INIs) are a class of antiretroviral drug designed to block the action of integrase, a viral enzyme that inserts the viral genome into the DNA of the host cell. Since integration is a vital step in retroviral replication, blocking it can halt further spread of the virus. Integrase inhibitors were initially developed for the treatment of HIV infection, but have been applied to other retroviruses. The class of integrase inhibitors called integrase strand transfer inhibitors (INSTIs) ar…

DA: 75 PA: 94 MOZ Rank: 68

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004278/

WEBSummary. In this review, we have summarized the current literature on clinically established IN inhibitors, their mechanism of action, the advantages and disadvantages associated with … Author: Jay Trivedi, Jay Trivedi, Dinesh Mahajan, Russell J. Jaffe, Arpan Acharya, Debashis Mitra, Debashis ... DOI: 10.1007/s11904-019-00480-3 Publish Year: 2020 Published: 2020/02

Author: Jay Trivedi, Jay Trivedi, Dinesh Mahajan, Russell J. Jaffe, Arpan Acharya, Debashis Mitra, Debashis ...

DOI: 10.1007/s11904-019-00480-3

Publish Year: 2020

Published: 2020/02

DA: 95 PA: 93 MOZ Rank: 68

medicalnewstoday.com

https://www.medicalnewstoday.com/articles/323882

WEBDec 4, 2018 · Integrase inhibitors, also called INSTIs, block the action of an enzyme, HIV integrase, which the virus needs in order to multiply. A …

DA: 44 PA: 23 MOZ Rank: 3

nih.gov

https://pubmed.ncbi.nlm.nih.gov/32860583/

WEBPMCID: PMC7572875. DOI: 10.1007/s40265-020-01379-9. Abstract. The newest class of antiretrovirals for all persons living with HIV are the integrase strand transfer inhibitors …

DA: 84 PA: 93 MOZ Rank: 89

sciencedirect.com

https://www.sciencedirect.com/science/article/pii/S0924857921000856

WEBMay 1, 2021 · Highlights. •. Integrase strand transfer inhibitors (INSTIs) are becoming more common in first-line antiretroviral therapy (ART). •. A limitation of INSTIs is potential cross …

DA: 65 PA: 80 MOZ Rank: 5

wiley.com

https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/phar.2246

WEBMar 12, 2019 · This review provides a brief overview of the INSTI class including agents currently available and those still in development, reviews available data from both completed and ongoing clinical trials, and outlines …

DA: 85 PA: 95 MOZ Rank: 71

nature.com

https://www.nature.com/articles/nrd1660

WEBFeb 24, 2005 · Integrase can be used for high-throughput screening and a variety of inhibitors from diverse chemical classes have been identified. Criteria required to demonstrate targeting of cellular integrase...

DA: 38 PA: 23 MOZ Rank: 12