Keyword Analysis & Research: increase clozapine level

nih.gov

https://pubmed.ncbi.nlm.nih.gov/22929408/

There seems to be 2 different mechanisms explaining the increase in clozapine levels in this patient. First, a downregulation of CYP enzyme activities, which primarily seems to be mediated by interleukin-6, takes place during infection and inflammation. Second, the concentration of the acute phase protein α1-acid glycoprotein (AGP; orosomucoid ... Author: Ketil Arne Espnes, Kent Ove Heimdal, Olav Spigset Publish Year: 2012

Author: Ketil Arne Espnes, Kent Ove Heimdal, Olav Spigset

Publish Year: 2012

DA: 6 PA: 40 MOZ Rank: 81

smiadviser.org

https://smiadviser.org/knowledge_post/clozapine-blood-levels

As clozapine is principally metabolized via CYP 1A2, strong CYP 2D6 or 3A4 inhibitors will typically increase clozapine levels by 40% – 100%, generating MR values in the range of 1.80 to 2.60. Conversely, strong 1A2 inhibitors (e.g. fluvoxamine, ciprofloxacin) may increase clozapine levels up to 10-fold, with resulting MR values of 3.00 or greater.

DA: 24 PA: 83 MOZ Rank: 23

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881106/

Nov 27, 2019 · The addition of 50 mg of fluvoxamine is reported to increase clozapine plasma concentrations by 120%, and the combination increases the ratio of clozapine to N-desmethylclozapine (NDMC or norclozapine), the primary metabolite.54 It was reported that a larger clozapine/norclozapine ratio may be more predictive for response than the clozapine … Author: James L. Roerig Publish Year: 2019

Author: James L. Roerig

Publish Year: 2019

DA: 25 PA: 98 MOZ Rank: 8

nih.gov

https://pubmed.ncbi.nlm.nih.gov/28392207/

Clozapine is the most effective anti-psychotic medication for treatment refractory schizophrenia. A growing number of case reports have linked infection to high clozapine levels and associated adverse outcomes. We present a systematic review of published cases to clarify the relationship between infection and elevated clozapine levels. Author: Scott R Clark, Nicola S Warren, Gajin Kim, David Jankowiak, Klaus Oliver Schubert, Steve Kisely, Tor... Publish Year: 2017

Author: Scott R Clark, Nicola S Warren, Gajin Kim, David Jankowiak, Klaus Oliver Schubert, Steve Kisely, Tor...

Publish Year: 2017

DA: 67 PA: 34 MOZ Rank: 94

psychiatryeducationforum.com

https://psychiatryeducationforum.com/medications-affect-clozapine-levels/

26 rows · Jun 14, 2021 · Serum Clozapine Level: CYP450: ANTIDEPRESSANTS: Fluvoxamine: Increase in Clozapine level: ...

DA: 15 PA: 60 MOZ Rank: 71

nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061735/

1 – 4 High clozapine levels are consistent with infection-related inflammation inhibiting cytochrome P450 1A2 (CYP1A2) and slowing clozapine metabolism. 5 We report a case of elevated clozapine levels following administration of an mRNA vaccine.

DA: 53 PA: 7 MOZ Rank: 1

mdedge.com

https://www.mdedge.com/psychiatry/article/63481/schizophrenia-other-psychotic-disorders/clozapine-drug-levels-guide-dosing

Adjusting clozapine dose Now that you have an accurate drug level, take advantage of clozapine’s linear pharmacokinetics. If you double the dose, you double the level; if you halve the dose, you halve the level. For example, consider the case of a schizophrenia patient who remains psychotic despite a clozapine dose of 200 mg bid (400 mg/d).

DA: 66 PA: 58 MOZ Rank: 67

cambridge.org

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S1742646413000332

with increase in clozapine levels include: erythromycin, ciprofloxacin, omeprazole, cimetidine, OCP containing ethinylestradiol, amiodarone, aluminum hydroxide and isoniazid. Rifampin and St John’s wort resulted in low clozapine levels. Smoking cessation also increased clozapine levels. The role of routine

DA: 36 PA: 27 MOZ Rank: 60