Keyword Analysis & Research: hfref


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Frequently Asked Questions

What is the difference between HFrEF and HFpEF?

HFpEF is a type of heart failure that occurs due to the inability of the left ventricle to relax properly. HFrEF is a type of heart failure that occurs due to the inability of the left ventricle to contract properly. So, this is the key difference between HFpEF and HFrEF.

What are the symptoms of HFrEF?

HFpEF and HFrEF are two types of heart failures based on the ejection fraction. In both types, the amount of blood pumped out to the body is less than the normal. Two types are related to the left ventricle of the heart. Fatigue and shortness of breath are common symptoms of both HFpEF and HFrEF.

What is the difference between HFrEF and HFpEF in terms of pathophysiology and etiology?

So, this is the key difference between HFpEF and HFrEF. Left ventricle fails to fill properly in HFpEF while the left ventricle fails to pump out an adequate amount of blood to the body in HFrEF. In HFpEF, ejection fraction is greater than 50% while in HFrEF, ejection fraction is lower than 40%. Moreover, HFpEF is predominant in females than males.

How is Hfref treated?

Unless there are specific contraindications, patients with HFrEF should be treated with a β-blocker and one of an angiotensin receptor-neprilysin inhibitor, angiotensin-converting enzyme inhibitor, or angiotensin receptor blocker as foundational therapy, with addition of a mineralocorticoid receptor antagonist in patients with persistent symptoms.


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