WebHuman chromosomes(grey) capped by telomeres (white) A telomere(/ˈtɛləmɪər,ˈtiːlə-/; from Ancient Greek τέλος(télos) 'end', and μέρος(méros) 'part') is a region of repetitive nucleotidesequences associated with specialized proteins at …
DA:94PA:19MOZ Rank:30
GGGCTA repeats can fold into hairpins poorly unfolded by
WebJul 21, 2021 · Abstract. Human telomeres are composed of GGGTTA repeats and interspersed with variant repeats. The GGGCTA variant motif was identified in the proximal regions of human telomeres about 10 years ago and was shown to display a length-dependent instability.
WebTelomeres. To prevent the loss of genes as chromosome ends wear down, the tips of eukaryotic chromosomes have specialized DNA “caps” called telomeres. Telomeres consist of hundreds or thousands of repeats of the same short DNA sequence, which varies between organisms but is 5'-TTAGGG-3' in humans and other mammals.
DA:36PA:45MOZ Rank:66
The DNA secondary structures at telomeres and genome instability
WebMar 26, 2020 · G-quadruplex and R-loops at telomeres or transcribed regions of genome have been considered as the potential targets for cancer therapy. Here we discuss the potentials to target the secondary structures (G4s and R-loops) in …
WebTelomeres and aging Telomeres play a central role in cell fate and aging by adjusting the cellular response to stress and growth stimulation on the basis of previous cell divisions and DNA damage. At least a few hundred nucleotides of telomere repeats must "cap" each chromosome end to avoid activation of DNA repair pat …
DA:51PA:71MOZ Rank:45
Telomeric G-quadruplexes are a substrate and site of ... - Nature
WebJul 9, 2015 · Nature Communications - G-quadruplexes formed by four guanine bases in a square planar arrangement in telomeres may prevent extension of this region by telomerase. Here, the authors show that ...
DA:81PA:18MOZ Rank:18
Telomeres: The Role of Shortening in Cancer and Aging, How to …
WebJun 26, 2018 · Telomeres are small structures that protect the ends of your chromosomes. Over time, they tend to get shorter. We’ll dive into the recent research surrounding telomere shortening, cancer, and aging.
DA:78PA:47MOZ Rank:86
First complete, gapless sequence of a human genome reveals …
WebMar 31, 2022 · Karen Miga, assistant professor of biomolecular engineering at UC Santa Cruz, co-led the Telomere-to-Telomere (T2T) Consortium, which has released the first complete, gapless assembly of a human genome sequence. (Photo by Carolyn Lagattuta) It took almost twice as long to finish the last 8% of the human genome as it did to …
WebJun 2, 2023 · A telomere is a region of repetitive DNA sequences at the end of a chromosome. Telomeres protect the ends of chromosomes from becoming frayed or tangled. Each time a cell divides, the telomeres become slightly shorter. Eventually, they become so short that the cell can no longer divide successfully, and the cell dies. Human …
Webtelomere, segment of DNA occurring at the ends of chromosomes in eukaryotic cells (cells containing a clearly defined nucleus). Telomeres are made up of repeated segments of DNA that consist of the sequence 5′-TTAGGG-3′ (in which T, A, and G are the bases thymine , adenine , and guanine , respectively).