Keyword Analysis & Research: dstat aml

chimerix.com

https://www.chimerix.com/our-focus/oncology/

DA: 67 PA: 47 MOZ Rank: 93

chimerix.com

https://ir.chimerix.com/news-releases/news-release-details/chimerix-presents-updated-results-phase-2-clinical-trial-dstat

DA: 78 PA: 95 MOZ Rank: 82

nih.gov

https://pubmed.ncbi.nlm.nih.gov/34619434/

WEBDociparstat sodium (DSTAT, CX-01) is a low anticoagulant heparin with multiple mechanisms of action, including inhibition of the CXCR4/ … Combination of dociparstat …

DA: 32 PA: 65 MOZ Rank: 69

chimerix.com

https://ir.chimerix.com/news-releases/news-release-details/chimerix-announces-initiation-phase-23-study-dstat-acute-lung

WEBApr 29, 2020 · In a recent Phase 2 Acute Myeloid Leukemia (AML) study DSTAT was well tolerated with adverse events similar across DSTAT and control groups. DSTAT is an …

DA: 17 PA: 98 MOZ Rank: 65

cancertherapyadvisor.com

https://www.cancertherapyadvisor.com/home/cancer-topics/hematologic-cancers/aml-leukemia-dociparstat-standard-chemotherapy/

WEBDec 20, 2021 · Clinicaltrials.gov. Dociparstat (DSTAT) in combination with standard chemotherapy for the treatment of acute myeloid leukemia (AML) (DASH AML). NCT04571645. Accessed December 15,...

DA: 70 PA: 15 MOZ Rank: 37

chimerix.com

https://www.chimerix.com/our-focus/oncology/

What Is AML?How Is Aml Treated?What Is The Prognosis of Aml with Treatment?Why Is Aml So Difficult to Treat?What Are Targeted Therapies?Why Do Existing Targeted Therapies Fall Short? AML is considered a heterogeneous disease, meaning there are a multitude of chromosomal abnormalities and gene mutations that can cause the diseaseAML cells develop from stem cells that undergo both genetic and epigenetic changes resulting in subpopulations of cells with different phenotypesSubpopulations of AML cells may contain distinct cellu AML is considered a heterogeneous disease, meaning there are a multitude of chromosomal abnormalities and gene mutations that can cause the disease AML cells develop from stem cells that undergo both genetic and epigenetic changes resulting in subpopulations of cells with different phenotypes Subpopulations of AML cells may contain distinct cellular abnormalities or mutations contribu… AML is considered a heterogeneous disease, meaning there are a multitude of chromosomal abnormalities and gene mutations that can cause the disease AML cells develop from stem cells that undergo both genetic and epigenetic changes resulting in subpopulations of cells with different phenotypes Subpopulations of AML cells may contain distinct cellular abnormalities or mutations contributing to treatment resistance

AML is considered a heterogeneous disease, meaning there are a multitude of chromosomal abnormalities and gene mutations that can cause the disease

AML cells develop from stem cells that undergo both genetic and epigenetic changes resulting in subpopulations of cells with different phenotypes

Subpopulations of AML cells may contain distinct cellular abnormalities or mutations contribu…

Subpopulations of AML cells may contain distinct cellular abnormalities or mutations contributing to treatment resistance

DA: 77 PA: 85 MOZ Rank: 36

uci.edu

https://clinicaltrials.icts.uci.edu/trial/NCT04571645

WEBDociparstat (DSTAT) in Combination With Standard Chemotherapy for the Treatment of Acute Myeloid Leukemia (AML) (DASH AML) a study on Acute Myeloid Leukemia …

DA: 56 PA: 23 MOZ Rank: 45

chimerix.com

https://ir.chimerix.com/news-releases/news-release-details/chimerix-presents-updated-results-phase-2-clinical-trial-dstat

WEBDec 9, 2019 · Mobilization of AML blasts and leukemic stem cells from the bone marrow has been associated with enhanced chemosensitivity and may be a primary mechanism …

DA: 55 PA: 97 MOZ Rank: 32

prnewswire.com

https://www.prnewswire.com/news-releases/chimerix-exclusive-worldwide-licensee-of-cantexs-investigational-product-dstat-has-announced-promising-topline-results-from-the-first-cohort-of-a-randomized-covid-19-clinical-trial-301236633.html

WEBFeb 26, 2021 · DSTAT, licensed to Chimerix in July 2019, is currently being studied in two disease indications, COVID-19-associated ALI and AML, and has other potential …

DA: 8 PA: 84 MOZ Rank: 92

chimerix.com

https://www.chimerix.com/wp-content/uploads/2021/07/Kovacsovics-2017-DSTAT-Ph2-AML.pdf

WEBLSCs employ CXCL12/CXCR4 to home toward protective marrow niches. Heparin disrupts CXCL12-mediated sequestration of cells in the marrow. CX-01 is a low-anticoagulant …

DA: 94 PA: 26 MOZ Rank: 58