Keyword Analysis & Research: dna polymerase proofreading function

wikipedia.org

https://en.wikipedia.org/wiki/Proofreading_(Biology)

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wikipedia.org

https://en.wikipedia.org/wiki/Proofreading_(Biology)

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khanacademy.org

https://www.khanacademy.org/science/biology/dna-as-the-genetic-material/dna-replication/a/dna-proofreading-and-repair

Mechanisms to correct errors during DNA replication and to repair DNA damage over the cell's lifetime. •Cells have a variety of mechanisms to prevent mutations, or permanent chang… •During DNA synthesis, most DNA polymerases "check their work," fixing th… What does DNA have to do with cancer? Cancer occurs when cells divide in an uncontrolled way, ignoring normal "stop… DNA polymerases are the enzymes that build DNA in cells. During DNA replicati… Many errors are corrected by proofreading, but a few slip through. Mismatch repair h… How does mismatch repair work? First, a protein complex (group of proteins) reco… Mismatch repair.

Mechanisms to correct errors during DNA replication and to repair DNA damage over the cell's lifetime.

•Cells have a variety of mechanisms to prevent mutations, or permanent chang…

•During DNA synthesis, most DNA polymerases "check their work," fixing th…

What does DNA have to do with cancer? Cancer occurs when cells divide in an uncontrolled way, ignoring normal "stop…

DNA polymerases are the enzymes that build DNA in cells. During DNA replicati…

Many errors are corrected by proofreading, but a few slip through. Mismatch repair h…

How does mismatch repair work? First, a protein complex (group of proteins) reco…

Mismatch repair.

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lumenlearning.com

https://courses.lumenlearning.com/wm-biology1/chapter/reading-proofreading-dna/

WEBIn proofreading, the DNA pol reads the newly added base before adding the next one, so a correction can be made. The polymerase checks whether the newly added base has paired correctly with the base in …

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nature.com

https://www.nature.com/articles/s41467-023-44198-8

WEBDec 27, 2023 · DNA polymerase (DNAP) can correct errors in DNA during replication by proofreading, a process critical for cell viability. However, the mechanism by which …

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libretexts.org

https://bio.libretexts.org/Bookshelves/Genetics/Working_with_Molecular_Genetics_(Hardison)/Unit_II%3A_Replication_Maintenance_and_Alteration_of_the_Genetic_Material/5._DNA_replication_I%3A_Enzymes_and_mechanism/Polymerases

WEBJun 20, 2023 · Ross Hardison. The Pennsylvania State University. Of all the enzymatic functions needed for replication of DNA, the ability to catalyze the incorporation of …

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wikipedia.org

https://en.wikipedia.org/wiki/Proofreading_(Biology)

OverviewBacteriophage T4 DNA polymeraseSARS-CoV-2 proofreading enzymeExternal linksBacteriophage (phage) T4 gene 43 encodes the phage’s DNA polymerase replicative enzyme. Temperature-sensitive (ts) gene 43 mutants have been identified that have an antimutator phenotype, that is a lower rate of spontaneous mutation than wild type. Studies of one of these mutants, tsB120, showed that the DNA polymerase specified by this mutant copies DNA templates at a slower rate than the wild-type polymerase. However, the 3’ to 5’ exonuclease activ…

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nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153641/

WEBMar 2, 2018 · A major function of replicative DNA polymerases is to replicate DNA with the very high accuracy. The fidelity of DNA replication relies on nucleotide selectivity …

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libretexts.org

https://bio.libretexts.org/Courses/Lumen_Learning/Biology_for_Non_Majors_I_(Lumen)/09%3A_DNA_Structure_and_Replication/9.08%3A_Proofreading_DNA

WEBFeb 28, 2021 · Identify the key proofreading processes in DNA replication. DNA replication is a highly accurate process, but mistakes can occasionally occur, such as a DNA …

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khanacademy.org

https://www.khanacademy.org/science/ap-biology/gene-expression-and-regulation/replication/a/molecular-mechanism-of-dna-replication

WEBKey points: DNA replication is semiconservative. Each strand in the double helix acts as a template for synthesis of a new, complementary strand. New DNA is made by enzymes …

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nature.com

https://www.nature.com/articles/s41594-023-01001-y

WEBMay 18, 2023 · The correction of errors during mitochondrial DNA replication by the proofreading function of DNA polymerase-γ is crucial for maintaining the integrity of …

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nature.com

https://www.nature.com/articles/s41467-023-44198-8.pdf

WEBDNA polymerase (DNAP) can correct errors in DNA during replication by proofreading, a process critical for ce ll viability. However, the mechanism by...

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