Cardiac glycoside poisoning (including digoxin) - EMCrit Project
https://emcrit.org/ibcc/dig/
Mechanism of Action of DigoxinDigoxin IntoxicationOther Cardiac GlycosidesAcute vs. Chronic ToxicityA Variety of Arrhythmias May Be SeenGINeurologicEkg Revealing Digitalis EffectCommon Differential Diagnostic ConsiderationsRelated Differential Diagnoses (1) Digoxin inhibits the cardiac Na/K antiporter (orange oval, above). This causes an increase in intracellular sodium and a decrease in intracellular potassium.(2) The increase in intracellular sodium causes an increase in excretion of sodium through the Na/Ca exchanger, which in turn increasesintracellular calcium levels.(3) Increased intracellular calcium increases inotropy. (1) Digoxin inhibits the cardiac Na/K antiporter (orange oval, above). This causes an increase in intracellular sodium and a decrease in intracellular potassium.(2) The increase in intracellular sodium causes an increase in excretion of sodium through the Na/Ca exchanger, which in turn increasesintracellular calcium levels.(3) Increased intracellular calcium increases inotropy.(4) Increased inotropy often causes a reflexive increase in vagal tone. For patients in atrial fibrillation, increased vagal tone will decrease the conduction rate through the atrioventricular node... (1) Digoxin inhibits the cardiac Na/K antiporter (orange oval, above). This causes an increase in intracellular sodium and a decrease in intracellular potassium. (2) The increase in intracellular sodium causes an increase in excretion of sodium through the Na/Ca exchanger, which in turn increasesintracellular calcium levels. (3) Increased intracellular calcium increases inotropy. (1) Digoxin inhibits the cardiac Na/K antiporter (orange oval, above). This causes an increase in intracellular sodium and a decrease in intracellular potassium. (2) The increase in intracellular sodium causes an increase in excretion of sodium through the Na/Ca exchanger, which in turn increasesintracellular calcium levels. (3) Increased intracellular calcium increases inotropy. (4) Increased inotropy often causes a reflexive increase in vagal tone. For patients in atrial fibrillation, increased vagal tone will decrease the conduction rate through the atrioventricular node...
(1) Digoxin inhibits the cardiac Na/K antiporter (orange oval, above). This causes an increase in intracellular sodium and a decrease in intracellular potassium.
(2) The increase in intracellular sodium causes an increase in excretion of sodium through the Na/Ca exchanger, which in turn increasesintracellular calcium levels.
(3) Increased intracellular calcium increases inotropy.
(4) Increased inotropy often causes a reflexive increase in vagal tone. For patients in atrial fibrillation, increased vagal tone will decrease the conduction rate through the atrioventricular node...
DA: 41 PA: 63 MOZ Rank: 90