delta aminolevulinic acid synthase | Aminolevulinic acid synthase

Keyword	CPC	PCC	Volume	Score	Length of keyword
delta aminolevulinic acid synthase	0.23	0.5	6358	16	34
delta	1.74	0.6	2662	1	5
aminolevulinic	0.57	0.3	5175	5	14
acid	1.52	1	7802	4	4
synthase	1.91	0.5	1498	90	8

Keyword	CPC	PCC	Volume	Score
delta aminolevulinic acid synthase	1.73	0.2	5923	55
delta-aminolevulinic acid	1.26	0.7	1686	56
what synthesizes aminolevulinic acid synthase	1.48	0.6	4014	7
delta-aminolevulinic acid dehydratase	1.35	0.5	515	34
5-aminolevulinic acid synthase	1.17	0.5	8783	20
delta ala synthase 2	1.17	0.9	9855	46
delta-aminolevulinate	0.57	1	2193	71
aminolevulinate delta- dehydratase	1.24	0.6	1989	69
delta aminolevulinic acid random urine	1.89	0.5	4351	67
5-aminolevulinate synthase	1.69	1	9795	96
delta-selinene synthase	1.49	0.8	7750	23
d-aminolevulinic acid	1.41	1	911	98

Search Results related to delta aminolevulinic acid synthase on Search Engine

Aminolevulinic acid synthase - Wikipedia
wikipedia.org

https://en.m.wikipedia.org/wiki/Aminolevulinic_acid_synthase

WEBAminolevulinic acid synthase (ALA synthase, ALAS, or delta-aminolevulinic acid synthase) is an enzyme (EC 2.3.1.37) that catalyzes the synthesis of δ-aminolevulinic acid (ALA) the first common precursor in the biosynthesis of all tetrapyrroles such as hemes, cobalamins and chlorophylls.

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Aminolevulinic acid - Wikipedia
wikipedia.org

https://en.m.wikipedia.org/wiki/Aminolevulinic_acid

WEBδ-Aminolevulinic acid (also dALA, δ-ALA, 5ALA or 5-aminolevulinic acid), an endogenous non-proteinogenic amino acid, is the first compound in the porphyrin synthesis pathway, the pathway that leads to heme in mammals, as well as chlorophyll in plants. 5ALA is used in photodynamic detection and surgery of cancer.

DA: 47 PA: 62 MOZ Rank: 56

Biochemistry, Heme Synthesis - StatPearls - NCBI Bookshelf
nih.gov

https://www.ncbi.nlm.nih.gov/books/NBK537329/

WEBMay 1, 2023 · 5'-Aminolevulinic acid synthase (ALA-S) is the regulated enzyme for heme synthesis in the liver and erythroid cells. There are two forms of ALA Synthase, ALAS1, and ALAS2. All cells express ALAS1 while only the liver and bone marrow expresses ALAS2. The gene for ALAS2 is on the X-chromosome.

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Porphyria | New England Journal of Medicine
nejm.org

https://www.nejm.org/doi/full/10.1056/NEJMra1608634

WEBAug 31, 2017 · Delta aminolevulinic acid dehydratase deficiency and uroporphyrinogen-III synthase deficiency (in congenital erythropoietic porphyria) 3,4 are very rare and will not be discussed. Table 1....

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A method for determining δ-aminolevulinic acid synthase activity …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522353/

WEBIn mammalian cells the rate-limiting step in heme biosynthesis is the formation of δ-aminolevulinic acid (ALA). The reaction intermediates, porphyrins and iron and the final product, heme can be highly cytotoxic if allowed to accumulate.

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Delta-aminolevulinic acid synthase (ALA synthase) reaction
utah.edu

https://library.med.utah.edu/NetBiochem/hi31.htm

WEBJan 5, 1995 · The delta-aminolevulinic acid (pronounce) synthase (ALA synthase) reaction occurs in the mitochondria. The substrates are. succinyl CoA (from the tricarboxylic acid cycle) glycine (from the general amino acid pool) An essential cofactor is pyridoxal phosphate (vitamin B-6). The reaction is sensitive to nutritional deficiency of this vitamin.

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Structural basis for dysregulation of aminolevulinic acid synthase …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892079/

WEBJan 28, 2022 · Aminolevulinic acid synthase (ALAS) initiates heme biosynthesis in α-proteobacteria and nonplant eukaryotes. Debilitating and painful diseases such as X-linked sideroblastic anemia and X-linked protoporphyria can result from one of more than 91 genetic mutations in the human erythroid-specific enzyme ALAS2.

DA: 1 PA: 10 MOZ Rank: 40

Biosynthesis of delta-aminolevulinic acid and the regulation …
jbc.org

https://www.jbc.org/article/S0021-9258(18)54738-4/pdf

WEBBiosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man. THE JOURNAL OF BIOLOGICAL CHEMISTRY. IC 1991 by The American Society for Biochemistry and Molecular Biology, Inc. Vol. 266, No. 32, Issue of November 15, pp. 22010-22018,1991.

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Aminolevulinic Acid Synthase - an overview - ScienceDirect
sciencedirect.com

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/aminolevulinic-acid-synthase

WEB5-Aminolevulinic Acid Synthase. ALA synthase catalyzes the condensation of glycine and succinyl coenzyme A to form ALA using pyridoxal phosphate as a cofactor ( Figure 3 ). The enzymology of mammalian ALA synthase is worked out in detail, and is generally applicable to the synthases from other organisms based on structural similarities.

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Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent
nejm.org

https://www.nejm.org/doi/full/10.1056/NEJMoa1807838

WEBFeb 6, 2019 · Induction of delta aminolevulinic acid synthase 1 ( ALAS1) gene expression and accumulation of neurotoxic intermediates result in neurovisceral attacks and disease manifestations in...

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