There is no direct connection from Tampa to Key West. However, you can take the bus to Naples, take the taxi to Marco Island, FL, then take the ferry to Key West, FL. Alternatively, you can take a vehicle from Tampa to Key West via Ft Myers, Fl,...How do you drive to Key West?
If you start at one end of the Keys at Key Largo and drive all the way down to as far as you can go to Key West it is 97.6 miles, which should take you about 2 hours and 4 minutes to do on the US1.Is there ferry from Fort Myers to Key West?
The ferry sets sail from Matanzas Harbor on San Carlos Island (just north of Fort Myers Beach) every day (seasonally) at 8:30 a.m. and arrives in Key West at noon, while the ferry going the other direction leaves Key West at 6 p.m. and gets into Fort Myers at 9:30 p.m..Can You Drive to the Florida Keys?
Driving Time to the Keys. You can Fly or Drive to the Florida Keys. The major U.S. airlines continue to offer convenient flights to the Florida Keys. However, our islands are the only tropical getaway reachable by car from the U.S. mainland.